Lipogaine is a minoxidil-based topical hair loss treatment. As the only FDA-approved treatment for hair loss in women, Minoxodil more recognizably is sold under the name of Rogaine.
Lipogaine claims to be a huge improvement on this popular hair loss treatment.
Compared to Rogaine, the Lipogaine solution that contains wider variety of ingredients that help with female hair loss. (Lipogaine also offers a robust product line for men).
Also, for those of us with sensitive scalps, Lipogaine claims to be a more tolerable formulation for our finicky skin.
Because I and probably most of my readers have a sensitive scalp, I will be focusing on that version of Lipogaine for Sensitive Scalp in this review.
What’s in Lipogaine?
First off, what’s NOT in Lipogaine: propylene glycol. This is the ingredient responsible for so much of the scalp irritation experienced by those who have tried and ultimately set aside Rogaine.
Lipogaine contains the following ingredients:
Minoxidil: Minoxidil is the FDA approved and most widely used ingredient in hair regrowth products as of today. It was first used as an oral drug to lower blood pressure. It was soon found to stimulate hair growth.
Rigorous clinical studies have confirmed this “side effect” and its FDA approvals for hair re-growth as topical solutions were granted.
AzetinolTM: A proprietary extract of natural grains. Grains rich in fatty acids, linoleic acid, oleic acid, and vitamin A are processed and extracted to enrich powerful DHT blocking components.
Castor oil: Castor oil has long been used as a natural remedy to combat hair loss and help hair grow fast. It’s antibacterial and anti fungal properties make it beneficial against folliculitis, dandruff and scalp infections, the common cause for hair loss. Caster oil is rich in ricinoleic acid, which helps increase circulation to the scalp and improve hair growth.
Ricinoleic acid also helps balance scalp pH and replenish the scalp’s natural oils and undo some of the damage of harsh chemical hair products. The antioxidants in castor oil also support the keratin in hair and help make hair stronger, smoother and less frizzy.
In the 2014 study published in British Journal of Dermatology, a team of renowned academic researchers discovered that hair follicles extracted from human males in presence of low concentration of caffeine showed significant hair growth and prolonged growth phase compared to the hair follicles cultured in pacebo solution.
The study found the caffeine also had a beneficial effect on female hair growth as well. Currently there are caffeine based hair loss shampoo from a number of different companies such as Men+Care Thick & Strong Fortifying 2 in 1 Shampoo + Conditioner by Dove, and Alpecin shampoo by Dr. Kurt Wolff GmbH.
Saw Palmetto: (Serenoa repens or Sabal serrulata): A dwarf palm plant native to North America. It primarily grows along the Atlantic coast in Georgia and Florida. The active ingredients are believed to be found in the plant’s brown-black berries.
It’s a popular dietary supplement for conditions associated with benign prostate gland enlargement (called benign prostatic hyperplasia, or BPH).
Study shows Saw Palmetto may work similarly to finasteride. [Comparitive effectiveness of finasteride vs Serenoa repens in male androgenetic alopecia: a two-year study. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1167-73.]
Biotin: One of the most important vitamins that improve the nail cell health and skin cell. It was discovered that certain foods contain this vitamin, and if you do not have it in sufficient quantity hair and nails become brittle.
The oil was used traditionally to treat a variety of skin diseases. Its natural properties are a tremendous boon for a scalp plagued by dandruff and irritation.
Argan oil is rich in natural phenols that are beneficial to hair follicles. Not only does it promote new hair growth, but also will help you grow healthy, thick looking hair.
Many beauticians and dermatologists recommend Argan oil as a cosmetic treatment for the hair and skin. We recommend Argan oil for a healthy head of hair alongside the big three hair loss treatment regimen.
Emu Oil: An anti-inflammatory natural tissue nutrient, full of healthy omega oils that support heal and rejuvenate the skin, as well as deeply moisturize. A recent Boston University study found that emu oil “remarkably” increased the thickness of the scalp skin and awakened dormant hair follicles.
Retinol: studies showed that combining minoxidil and retinol works better than minoxidil alone due to the enhanced penetration of minoxidil and improved scalp condition [Yoo HG et al, “the additive effects of minoxidil and retinol on human hair growth in vitro.” Bio Pharm Bull. 2007, 20(1): 21-6].
Procyanidin Oligomers: Naturally derived ingredients that have shown to stimulate hair growth similarly to Minoxidil. Research studies have shown that procyanidin oligomers possess growth stimulation activity toward hair epithelial cells in vitro and stimulate anagen induction in hair follicles in vivo.
GLA, ALA, Linoleic Acid, and Oleic Acid: Gamma Linolenic Acid (GLA), Alpha Linolenic Acid (ALA), linoleic and oleic acid are essential fatty acids found in plant oils, which have been demonstrated to interferes the binding of DHT to proteins in in vitro study. Additionally GLA, ALA and oleic acid also presents some anti-inflammatory properties.
What does all that mean?
Looking further into this, I realized how much each ingredient works to enhance the effectiveness of Lipogaine as a whole.
Who knew that minoxidil alone could not be as effective if not combined with retinol: the combination of the two has far better results of improving scalp condition than using minoxidil alone. The mixture of minoxidil and retinal allows for deeper penetration of minoxidil in the skin.
Even AzenitolTM, due to its properties containing fatty acids such as linoleic acid, oleic acid, and vitamin A, is a strong DHT blocker that works in harmony with minoxodil.
In summary, Lipogaine took something tried and proven for hair loss treatment, Minoxidil, and beefed it up with all kinds of synergistic helpers to make it even more effective. Cool!
Why Choose Lipogaine?
The web is full of enthusiastic reviews for Lipogaine. Many of these reviewers describe their prior experiences with other hair loss and minoxidil-based product, and the success they have with Lipogaine.
There are several reviews specifically from African-American women citing its great effect on hair regrowth around their edges and temples. Very cool!
Generally speaking, many people see results in 1-2 months, along with a thickening of their hair and improvement of hair growing in temples and along the hairline.
The side effects of Lipogaine can include, but aren’t limited to, the side effects to Minoxidil.
For fewer than 1% of uses those can be: unwanted facial/body hair, dizziness, fast/irregular heartbeat, fainting, chest pain, swelling of hands/feet, unusual weight gain, tiredness, difficulty breathing especially when lying down.
Stop using any minoxidil product immediately if this happens.
Lipogaine for women (Sensitive) does not include propylne glycol, which is responsible for many of the common negative reactions to other minoxidil formulations.
Also, Lipogaine (excluding only Lipogaine Shampoo) contains alcohol, which will cause burning or irritation of the eyes. If the hair regrowth solution accidentally gets into your eyes, rinse thoroughly with cool tap water.
How to Use Lipogaine:
Lipogaine is applied to dry hair (or towel dried hair which is less than 2 inches long). You may wash your hair 3 hours after applying the solution.
The included dropper applicator makes Lipogaine easy to use. Just fill the dropper up to the desired amount, and proceed to move the dropper close to the area you wish to treat.
Slowly squeeze the solution out, so that it does not run directly off the scalp.
Be sure the solution comes into contact with the scalp and not just the hair. This is crucial, so that the solution can be absorbed into the scalp around the thinning areas.
Use your fingertips to rub it into your scalp – the whole process just takes a few minutes.
Sometimes Lipogaine leaves a little residue, and in this case it’s best to use it at night before bed and simply wash it out in the morning. Also noteworthy: this product has no smell.
Thoughts about Lipgaine, Rogaine, or any other way to hair gain (hehe)? I’d love to hear your thoughts, ideas, comments, feedback, questions, and random musings about anything at all. Leave a comment and I’ll get back to you soon!